A road less traveled paved by IDO silencing
نویسندگان
چکیده
Orchestrating a cytotoxic polymorphonuclear neutrophil (PMN) response strictly focused within the tumor tissue remains a formidable challenge for the successful therapeutic use of these cells. A Salmonella vector carrying an shRNA against indoleamine 2,3-dioxygenase has been shown to recruit PMNs and enhance their activation specifically in the tumor bed, resulting in significant anticancer effects.
منابع مشابه
Estimating sediment yield from a paved forest road (Asphalt) (Case study: Watershed Leyle, Ravansar)
Extended abstract 1- Introduction Forest roads are among the largest sediment transport sources to drainage network. So, estimating the sediments of the road network is an important factor in the evaluation of the impact of the road construction. One of the biggest problems caused by the road construction in the forest is the increase in various forms of erosion, such as Gully erosion and mas...
متن کاملVehicle-Based Road Dust Emissions Measurements
TRAKER is a vehicle-based method for measuring road dust emissions. Particulate matter is sampled in front and behind a vehicles tire and the difference in PM concentration (TRAKER signal) is used to infer the airborne flux of particles from the roadway. Two independent tests indicated that the TRAKER signal increases as the cube of the speed for a given road dust loading. Simultaneous measure...
متن کاملRegional analysis of the effect of paved roads on sodium and chloride in lakes.
Salinization of surface water from sodium chloride (road salt) applied to paved roads is a widely recognized environmental concern in the northern hemisphere, yet practical information to improve winter road management to reduce the environmental impacts of this deicer is lacking. The purpose of our study was to provide such information by developing baseline concentrations for sodium and chlor...
متن کاملDiversity, seasonality, and context of mammalian roadkills in the southern Great Plains.
Thousands of mammals are killed annually from vehicle collisions, making the issue an important one for conservation biologists and environmental managers. We recorded all readily identifiable kills on or immediately adjacent to roads in the southern Great Plains from March 2004-March 2007. We also recorded distance traveled, whether a road was paved or divided, the number of lanes, and prevail...
متن کاملReinstalling antitumor immunity by inhibiting tumor-derived immunosuppressive molecule IDO through RNA interference.
Tumor-derived immune suppression is a major impediment to successful immune/gene cancer therapy. In the present study, we describe a novel strategy to disrupt tumor-derived immune suppression by silencing a tolerogenic molecule of tumor origin, IDO, using small interfering RNA (siRNA). Silencing of IDO in B16F10 cells in vitro using IDO-siRNA prevented catabolism of tryptophan and inhibited apo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 2 شماره
صفحات -
تاریخ انتشار 2013